ABSTRACT
Kaposi's sarcoma is the most frequent neoplasia related to AIDS. We report here the difficulties of diagnosis and therapeutic of an atypical cutaneous form of Kaposi's sarcoma. A 31-year-old woman HIV- infected with severe immunodeficiency [CD4 cell count is 50 cell/mm[3] and HIV RNA viral load is 539000 copies /ml] was admitted for an atypical cutaneous kaposi's sarcoma. She was first treated by antiretroviral therapy combined stavudine, lamivudine and indinavir added to bleomycm monochimiotherapy. One month after, she developed persistent cough and new lesions of Kaposi sarcoma which a big pseudotumoral frontal one. Bronchoscopy showed pulmonary Kaposi's sarcoma. Polychimiotherapy [bleomycin, donorubicin et vinblastin], and local treatment were instituted with regression of lesions. Combined antiretroviral therapy, by increasing immune restoration, leaded to recovery